Optimal meropenem concentrations to treat multi - drug 2 resistant Pseudomonas aeruginosa septic shock 3 4 5
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چکیده
Optimal meropenem concentrations to treat multi-drug 2 resistant Pseudomonas aeruginosa septic shock 3 4 5 Fabio Silvio Taccone, Frédéric Cotton, Sandrine Roisin, 6 Jean-Louis Vincent, Frédérique Jacobs 7 8 1 Department of Intensive Care 9 Hôpital Erasme, Université Libre de Bruxelles 10 Route de Lennik, 808 11 1070 Brussels, Belgium 12 13 2 Department of Clinical Biology 14 Hôpital Erasme, Université Libre de Bruxelles 15 Route de Lennik, 808 16 1070 Brussels, Belgium 17 18 3 Department of Microbiology 19 Hôpital Erasme, Université Libre de Bruxelles 20 Route de Lennik, 808 21 1070 Brussels, Belgium 22 23 4 Department of Infectious Diseases 24 Hôpital Erasme, Université Libre de Bruxelles 25 Route de Lennik, 808 26 1070 Brussels, Belgium 27 28 29 30 31 32 33 Correspondence: 34 35 Dr Fabio Silvio TACCONE 36 Department of Intensive Care 37 Hôpital Erasme, Université Libre de Bruxelles 38 Route de Lennik, 808 39 1070 Brussels, Belgium 40 Tel: +3225555587 41 Fax: +3225554698 42 Email: [email protected] 43 44 45 46 47 48 49 Copyright © 2012, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.06389-11 AAC Accepts, published online ahead of print on 30 January 2012
منابع مشابه
Optimal meropenem concentrations to treat multi - drug 2 resistant Pseudomonas aeruginosa septic shock 3 4 5 Fabio
Optimal meropenem concentrations to treat multi-drug 2 resistant Pseudomonas aeruginosa septic shock 3 4 5 Fabio Silvio Taccone, Frédéric Cotton, Sandrine Roisin, 6 Jean-Louis Vincent, Frédérique Jacobs 7 8 1 Department of Intensive Care 9 Hôpital Erasme, Université Libre de Bruxelles 10 Route de Lennik, 808 11 1070 Brussels, Belgium 12 13 2 Department of Clinical Biology 14 Hôpital Erasme, Uni...
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A patient with septic shock due to extensively drug resistant (XDR) Pseudomonas aeruginosa was cured by optimizing the meropenem (MEM) regimen to obtain at least 40% of the time between two administrations in which drug levels were four times higher than the MIC of the pathogen. As the standard drug dose did not achieve these optimal concentrations, the MEM regimen was progressively increased u...
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Multiple-drug-resistant mutants were isolated from Pseudomonas aeruginosa PAO1 on agar plates containing ofloxacin and cefsulodin. These mutants were four to eight times more resistant to meropenem, cephems, carbenicillin, quinolones, tetracycline, and chloramphenicol than the parent strain was. In contrast, these mutants showed no significant changes in their susceptibilities to all carbapenem...
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